About The ASCR Network
The Adult Stem Cell Research (ASCR) Network is an internet-based project of the Cell Therapy Foundation designed to be a well-maintained and reliable source of information for physicians and the public regarding adult stem cell research. ASCR seeks to disseminate the latest scientific news in the adult stem cell arena, identify leading researchers in the field, and locate key clinical trials in order to help patients and research unite in a beneficial and timely manner.
Additionally, a future goal of the ASCR Network is to be a community of education and collaboration where news, ideas and research will merge in real-time with the aim of translating the best therapeutic practices to the patient in the most efficient, lay-friendly way possible.
While much progress has been made in the last few years, many therapies are still experimental and/or not ready for use in human trials. The Cell Therapy Foundation and ASCR Network seek to breach that gap by information sharing and collaboration. Consider partnering with us in this cause. Your vital donation will help support our efforts to transform a mere experiment in the lab today into a cure for thousands of patients tomorrow! Click here to donate.
ADULT STEM CELL NEWS
Find links below to the latest news and developments
in the adult stem cell sector from around the world.
Protein factors in wall of cell nuclei may help direct stem cell movement
February 26, 2014
Researchers from the University of Pennsylvania took a fascinating look into the nuclei of adult stem cells and cancer cells and discovered that the proteins which surround the cell nucleus – and make the nucleus wall firm or flexible – may play a key role in how stem cells can get around the body and, potentially, to the site of injury. By stimulating and observing two nuclear proteins - lamin-A and “heat shock factors” - scientists observed the delicate interplay that exists between nuclear wall flexibility and either successful cell migration or cell death.
Successful reprogramming of endoderm into functioning liver cells brings hope to patients with liver disease
February 25, 2014
Researchers at Gladstone Institutes and the University of California, San Francisco, took a fresh approach to producing stem cell-derived liver cells and the results look encouraging.
Using a blend of genes and compounds, researchers successfully baited skin cells to return to endoderm-like tissue (rather than a state of pluripotency, which had proven unsuccessful in other liver reprogramming studies). After this successful transition, the scientists then coaxed the endoderm – via a different set of genes and compounds – to turn to liver cells and after only a few weeks, the transition was successful: functioning liver cells were observed.
Fate Therapeutics, Inc. announces promising results from its Phase 1b ProHema clinical trial
February 26, 2014
New data, published in a 2014 edition of Blood Cancer Journal and recently announced by Fate Therapeutics, Inc., indicates the results from the Phase 1b ProHema clinical trial looks promising.
Trial patient samples taken by Harvard-affiliated researchers indicate a significant increase in two CD8+ T cell fractions that are believed to help with immune reconstitution and viral immunity after a cord blood transplant: at 100 days post transplant, the researchers discovered a two-fold increase in both naïve and early memory T cells within the CD8+ T cell compartment, when compared to the patients who did not receive PROHEMA.
New European clinical trial seeks to increase heart attack survival rate using adult stem cells
The UK's London Chest Hospital has undertaken a new clinical trial which hopes to boost heart attack survival rates by about 25% for patients who are treated in the study.
The new trial, titled “"The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction” or “BAMI” for short, seeks to enroll 3000 patients who have suffered a heart attack and inject autologous bone-marrow-derived adult stem cells into their cardiac tissue within 5 days of the attack. The trial is a collaboration of 19 partners from across Europe and is funded by a multi-million dollar award from the European Commission.
* Designates sites with available clinical trials.
- * Adult Stem Cell Laboratory, Medical College of Georgia
- * Feinberg Cardiovascular Research Institute - Northwestern University, Chicago, IL
- * Indiana Center for Vascular Biology and Medicine, Laboratories - Indianapolis, IN
- * Regenerative Medicine Institute, Mexico
- * Stem Cell Center at Texas Heart Institute - Houston, TX
- Adipose Stem Cell Center, University of Pittsburgh - Pittsburgh, PA
- Adipose Tissue Plasticity - Toulouse France
- Adult Stem Cell Laboratory - Seoul, South Korea
- Adult Stem Cell Research Ctr, Seoul National University - Seoul, South Korea
- The Cardiovascular Research Institute - Washington, DC
- Center for Cardiovascular Cell Therapy - Louisville, KY
- Division of Clinical Immunology and Transfusional Medicine - Stockholm, Sweden
- Excellion Biomedical Services - Petropolis, Rio de Janeiro
- Interdisciplinary Stem Cell Institute/UM Med - Miami, FL
- Institute of Cell and Molecular Science - London, England
- Kolonin Lab - Centre for Stem Cell Research - Houston, TX
- Laboratory for Stem Cell Injury - Charleston, SC
- LIT - Laboratory of Transplantation Immunobiology - Sao Paulo, Brazil
- Minneapolis Heart Institute Foundation - Minneapolis, MN
- Molecular Cardiology Laboratory - ThoraxCenter - Rotterdam, Netherlands
- National Centre for Adult Stem Cell Research at Griffith University - Nathan Queensland, Australia
- Naviaux Lab - The Mitochondrial and Metabolic Disease Center - San Diego, CA
- Oklahoma Center for Adult Stem Cell Research (OCASCR) - Oklahoma City, OK
- Penn Lab - Cleveland Clinic - Cleveland, OH
- Prantl Laboratory - Center for Adult Stem Cell Research - Regensburg, Germany
- Research & Development Unit - National Heart Centre, Singapore
- RhinoCyte™, Inc. - Louisville, KY
- Scandurro Research Laboratory - New Orleans, LA
- Simari Lab - Mayo Clinic - Rochester, MN
- Skeletal Tissue Engineering Group - Amsterdam
- Skeletal Research Center, Case Western Reserve University - Cleveland, OH
- Stem Cell Biology Laboratory, Pennington Biomedical Research Center - Baton Rouge, LA
- Stem Cell Biology and Cell Therapy Laboratory - Philadelphia, PA
- Stem Cell Research Center - Pittsburgh, PA
- Stem Cell Research Center - Taipei, Taiwan
- Yoder Laboratory - Indianapolis, IN
- Wake Forest Institute of Regenerative Medicine - Winston-Salem, NC